Recent studies showed that reverse Warburg metabolism creates a metabolic niche for stem cell-like properties, giving rise to chemoresistant- and tumor relapse-initiating cancer cells [32,36,47,48], which mainly accounts for the poor prognosis of cancer patients associated with tumoral SLC16A1 expression [31,49,50,51,52]. The gene discussed is SLC16A1; the disease is neoplasm.