The complex and multifaced pathogenetic link of COVID-19 with the risk of thrombotic events involves several mechanisms, including the activation of platelets, complement system, and coagulation cascade, fibrinolysis, inflammatory cytokines release, immunothrombosis, production of antiphospholipid antibodies, and imbalance of the von Willebrand factor (vWF)/ADAMTS13 axis [1]. Here, ADAMTS13 is linked to COVID-19.