HMOX1 and Cognitive impairment: Research by Rinwa and colleagues demonstrated that piperine attenuated cognitive impairment and neuroinflammatory responses in a chronic unpredictable stress murine model [45], whereas separate investigations revealed that myricetin conferred neuroprotection through facilitation of Nrf2 nuclear translocation and upregulation of heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO 1) expression, concurrently decreasing MDA concentrations and enhancing SOD/catalase enzymatic activities in cuprizone-treated mice [9,46].