DUX4 and acute lymphoblastic leukemia: Of these, it is worth mentioning the translocation of DUX4, encoding a double-homeobox transcription factor, to the immunoglobulin heavy-chain locus (IGH) that is found in 5–10% of B-ALL or the ETV6-RUNX1-like ALL occurring almost exclusively in children (representing ~3% of pediatric ALL) and associated with a relatively favorable prognosis [47].