Several distinct genetic subgroups have been identified, including core-binding factor (CBF) AML, KMT2A/11q23 rearrangement AML, normal karyotype AML with somatic mutations, AML with unbalanced cytogenetic abnormalities, nucleoporin (NUP)98 11p15/NUP09 rearrangement AML, and acute promyelocytic leukemia (APL) with the PML–RARA rearrangement [56]. The gene discussed is KMT2A; the disease is acute myeloid leukemia.