In head and neck squamous cell carcinoma, Rap1GAP is repressed via EZH2, itself regulated by miR-101 and miR-26a, linking Rap1 to tumor invasion through a miR-101 → EZH2 → Rap1GAP → Rap1 axis [94,95,96]. The gene discussed is EZH2; the disease is head and neck squamous cell carcinoma.