EGF and epilepsy: To determine whether the decreased levels of PDGF-BB, EGF, BDNF, and MIF were specific to LD, we analyzed samples from patients suffering from other monogenic epilepsies, including Dravet syndrome disease (caused by a pathogenic genetic variant in the sodium channel SCN1A gene) and GLUT1 deficiency syndrome (caused by a pathogenic genetic variant in the glucose transporter SLC2A1 gene) (Table 1).