The CX3CL1/CX3CR1 axis is intricately involved in a variety of diseases, including renal disease, coronary artery disease, and malignancies, through the regulation of inflammatory leukocyte recruitment (such as macrophages, CD8+ T cells, and NK cells), cell survival, cytotoxic immune responses, and tissue fibrosis (Figure 2). Here, CD8A is linked to kidney disorder.