Considering an adjusted p-value of <0.05 and its biological relevance, the most enriched pathways were the p53 signaling pathway, TNF signaling pathway, chemokine signaling pathway, rheumatoid arthritis, focal adhesion, IL-17 signaling pathway, viral protein interaction with cytokine and cytokine receptor, calcium signaling pathway, long-term potentiation, and nucleotide metabolism, among others. The gene discussed is TNF; the disease is rheumatoid arthritis.