A diagnosis of hypereosinophilic asthma may be established by exclusion, following the confirmation of persistent eosinophilia (lasting ≥ 4 weeks), evidence of organ damage, and features of vasculitis, with special attention paid to the systematic reassessment of patients with ongoing hypereosinophilia despite having received anti-IL5/5R biologic therapy, and in patients with persistent eosinophilia while remaining on OCSs. Here, IL5 is linked to Increased total eosinophil count.