The most commonly mentioned signaling pathways that should be blocked to achieve an anti-tumor effect in CRC through repolarization of M2 macrophages to M1 include STATs (mainly STAT3 and STAT6) [94,103,104,179], NF-κB/MAPK [94,108], peroxisome proliferator-activated receptors (PPARs) [94], and HIFs [94,107]. This evidence concerns the gene STAT3 and colorectal carcinoma.