IGF1 and cancer: Many of these signaling molecules, including epidermal growth factor (EGF), fibroblast growth factor 2 (FGF-2), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), and transforming growth factor β (TGF-β), exert their pro-cancer mechanisms of action and affect the regulation of TAMs [6,7].