The induction of changes in macrophage polarization (a decrease in M2 and an increase in M1 macrophage population), the regulation of epithelial–mesenchymal transition (EMT) of CRC cells, and activation of phosphoinositide 3-kinase/serine/threonine kinase Akt (PI3K/AKT) signaling are also affected by proprotein convertase subtilisin/kexin type 9 (PCSK9). This evidence concerns the gene AKT1 and colorectal carcinoma.