Two sets of TAMs have been distinguished in CRC, which express different transcription factors, that is, avian musculoaponeurotic fibrosarcoma protooncogene/MAF homolog B (MAF/MAFB) and proto-oncogene C-Fos/Jun proto-oncogene (FOS/JUN) in complement C1q C chain (C1QC)+ TAMs, and CCAAT enhancer binding protein beta (CEBPB) and zinc finger E-box binding homeobox 2 (ZEB2) in secreted phosphoprotein 1 (SPP1)+ TAMs. This evidence concerns the gene SPP1 and colorectal carcinoma.