IL10 and hepatocellular carcinoma: For example, Koichi Yanaba’s published study revealed that the major phenotype of IL-10+ Breg after LPS stimulation is CD19+CD1dhiCD5+ [32]; another study showed that PD-1hi B cells play a significant role in suppressing immune responses in the hepatocellular carcinoma environment, and the major phenotype of Breg is CD5hiCD24−/+ CD27hi/+CD38dim [28].