In our previous studies, we demonstrated that isoflavonoid 8-hydroxydaidzein induced apoptosis by downregulating acute myeloid leukemia (AML)-associated genes such as RUNX1, CCND2, and MYC in U937 cells while upregulating CDKN1A (p21) and suppressing BCL2 expression in K562 cells [29,30,31]. Here, CDKN1A is linked to acute myeloid leukemia.