AKT1 and pulmonary fibrosis: In mice treated with BLM, atRA attenuated the upregulation of IL-17A, IL-10, IL-6, EphA2, EphriA1, PI3K 110γ, Akt, IL-6, TNF-α, and TGFβ1, which reduced pulmonary fibrosis and significantly alleviated lung fibrosis [141,142] (Figure 3).