Recent studies using Ingenuity Pathway Analysis (IPA) have identified the activation of multiple signaling networks involved in the progression from insulin-resistant and normal glucose tolerance individuals to T2DM patients: The NFKB1 network, as well as tumor necrosis factor, vascular endothelial growth factor, and interleukin1/1B Network [32]. The gene discussed is NFKB1; the disease is glucose measurement.