Compared with the findings reported by TCGA in 2015 [138] and Dono and colleagues [139], the observed PIK3CA mutation frequency in 1p/19q codeleted and IDH-mutant gliomas was lower in this cohort (10% versus 20% and 14%, respectively) [29], likely due to the more limited sequencing strategy. Here, IDH1 is linked to central nervous system cancer.