KAT8 acetylates NRF2 at lysine 588, facilitating its nuclear translocation and the activation of downstream oncogenes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HMOX1/HO-1), promoting NSCLC proliferation. Here, NFE2L2 is linked to non-small cell lung carcinoma.