KAT8 and neoplasm: YEATS domain-containing protein 4 (YEATS4), a conserved nuclear protein overexpressed in multiple cancers, was acetylated by KAT8 in bladder cancer cells, disrupting its interaction with HECT, UBA, and WWE domain containing E3 ubiquitin protein ligase 1 (HUWE1), inhibiting its ubiquitination and degradation, thereby suppressing tumor proliferation [15,16].