CircMYO10 has been shown to activate Wnt/CTNNB1 signaling via the miR-370-3p/RuvB-like AAA ATPase 1 (RUVBL1) axis and histone modifier lysine acetyltransferase 5 (KAT5/TIP60), increasing H4K16ac levels in the MYC proto-oncogene bHLH transcription factor (MYC/c-Myc) promoter to inhibit osteosarcoma progression [150]. The gene discussed is RUVBL1; the disease is osteosarcoma.