Ubiquitin-specific peptidase 10 (USP10) stabilized KAT8 and increased H4K16 acetylation in the promoter region of annexin A2 (ANXA2), activating Wnt/β-catenin (CTNNB1) signaling to promote ESCC cell migration and invasion [91]. The gene discussed is KAT8; the disease is esophageal squamous cell carcinoma.