In endometrial cancer cells, the estrogen/estrogen receptor upregulates KAT8 expression, activates the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) and Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathways to inhibit apoptosis of Ishikawa uterine cancer cells [52]. This evidence concerns the gene AKT1 and endometrial cancer.