In A549 NSCLC cells, KAT8 interacted with and acetylated LSD1, inhibiting LSD1 activity, which increased the methylation of histone H3 at lysine 4 in the promoters of KRT8 and cadherin 1 (CDH1/E-cadherin), upregulating their expression and promoting EMT and tumor invasion [97]. Here, KAT8 is linked to neoplasm.