Pyruvate kinase M1/2 (PKM/PKM2), a glycolytic regulator, interacted with and phosphorylated Bcl-2 apoptosis regulator (Bcl-2) to upregulate its expression [44], suppressing apoptosis in glioblastoma cells and promoting NSCLC cell proliferation [45]. Here, PKM is linked to non-small cell lung carcinoma.