Among them, the top ten highest degrees connected in the network were TNF (degree = 457), AKT1 (degree = 436), IL6 (degree = 426), IL1-beta (degree = 375), CD4 (degree = 369), SRC (degree = 342), EGFR (degree = 335), VEGFA (degree = 325), STAT3 (degree = 324), and TP53 (degree = 324), indicating that these targets are significant contributors to the pathogenesis of psoriasis. The gene discussed is AKT1; the disease is psoriasis.