The pathogenesis of vascular stenosis in MMD primarily involves concentric fibrocellular intimal hyperplasia, characterized by the proliferation and migration of ECs and SMCs, as well as extracellular matrix remodeling dominated by collagen deposition and elastin fragmentation, ultimately resulting in progressive intimal thickening and thus luminal occlusion [7]. The gene discussed is ELN; the disease is multiminicore myopathy.