The model for HF detection included an miRNA signature (miR-24-3p, miR-454-3p, miR-551b-3p, miR-10b-5p, miR-503-5p, miR-193a-5p, and miR-598-3p) that, when coupled with NT-proBNP, enhanced their diagnostic capability. This evidence concerns the gene NPPB and hydrops fetalis.