While TRIB3 expression is particularly elevated in fusion-positive ARMS—especially in tumors harboring the PAX3-FOXO1 fusion—it is also detectable at lower levels in fusion-negative RMS and is upregulated in other pediatric and adult sarcomas, including Ewing sarcoma, osteosarcoma, and myxoid liposarcoma. The gene discussed is TRIB3; the disease is Ewing sarcoma.