A hallmark of ARMS is the presence of chromosomal translocations, most commonly t(2;13)(q35;q14) and t(1;13)(q36;q14), which give rise to the chimeric transcription factors PAX3-FOXO1 and PAX7–FOXO1, respectively [12,13]. This evidence concerns the gene PAX3 and alveolar rhabdomyosarcoma.