Figure S1A highlights two representative miRNAs (miR141-3p and miR182-5p) that are significantly downregulated in the new-onset group (red) compared to the resilient group (blue). Network analysis of all differentially expressed miRNAs identified a targeted gene network focused on circadian genes CLOCK and BDNF, a key regulator of neuroplasticity and neuronal survival implicated in the pathophysiology of PTSD (Figure S1B). Here, BDNF is linked to post-traumatic stress disorder.