In a mouse model of endometriosis, F8-IL4 reduced the number and volume of lesions while lowering the expression of genes related to cell adhesion, invasion, and neovascularization, such as integrin β1, MMP-3, MMP-9, and VEGF, without affecting inflammatory cytokines.No clinical studies have been performed in humans. This evidence concerns the gene MMP9 and endometriosis.