The RBM15 gene that was predicted as a transcriptional DUX4 target from a previous ChIP-seq study on human myoblasts [46] was significantly upregulated in FSHD muscle biopsies as compared with healthy muscles and also had the same expression pattern in a previous study [50], further highlighting the potential involvement of DUX4 in RNA modifications and FSHD pathophysiology. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.