By examining the published transcriptome profiling data reported by our lab in 2007, we identified 5 out of 23 known m6A regulators that were significantly upregulated in FSHD muscles (Figure 1), including WT1-associated protein (WTAP) (log2FC: 0.51 p < 0.005), RNA binding motif protein 15 (RBM15) (log2FC: 0.84 p < 0.005), FTO alpha-ketoglutarate-dependent dioxygenase (FTO) (log2FC: 0.18 p < 0.05), YTH N6-methyladenosine RNA binding protein F2 (YTHDF2) (log2FC: 0.50 p < 0.05) and heterogeneous nuclear ribonucleoprotein C (HNRNPC) (log2FC: 0.46, p < 0.05). The gene discussed is FTO; the disease is facioscapulohumeral muscular dystrophy.