Among 4804 adult non-Hispanic white (NHW), non-Hispanic black (NHB), and Mexican American (MA) participants (1825 NHW, 1442 NHB, and 1537 MA; 51.7% women; mean age at examination, 42.5 y), the G allele of PNPLA3 rs738409 and the T allele of GCKR rs780094 were associated with hepatic steatosis with a high level of ALT (odds ratio [OR]: 1.36, p = 0.01, and OR: 1.30, p = 0.03, respectively) [53]. This evidence concerns the gene PNPLA3 and Hepatic steatosis.