SERPINA1 and Cirrhosis: Bridi et al. prospectively examined the PRS of the sum of risk alleles in PNPLA3, TM6SF2, and SERPINA1 minus the protective variant in HSD17B13 among 382 patients aged ≥ 50 years and with type 2 diabetes mellitus, and showed that a higher PRS is associated with an increased risk of cirrhosis (p = 0.037) and also that a high PRS is associated with an increased risk of advanced cirrhosis among those with a fibrosis-4 index <1.3 (p = 0.036) [95].