Zhang et al. fed hepatocyte-specific Tm6sf2 knockout mice with a high-fat/high-cholesterol (HFHC) diet or a diethylnitrosamine-plus-HFHC diet to induce MASLD-HCC, and they concluded that hepatic TM6SF2 protects against MASLD-HCC and activates cytotoxic CD8+ T cells via the NF-κß-IL6 axis [47]. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatotic liver disease.