Romeo et al. reported that an allele in PNPLA3 (rs738409: I148M) was strongly associated with increased hepatic fat levels (p = 5.9 × 10−10) and with hepatic inflammation (p = 3.7 × 10−4) by a GWAS, suggesting that this genetic variant may provide predictive information for the developmental risk of hepatic steatosis and liver injury [29]. Here, PNPLA3 is linked to fatty liver disease.