PNPLA3 and metabolic dysfunction-associated steatohepatitis: Gao et al. showed that the nomogram, which includes sex, metabolic syndrome, a homeostatic model assessment for insulin resistance (HOMA-IR), AST levels, and the PNPLA3 and HSD17B13 genotypes, is useful, and that individualized PRSs can identify MASH in the Eastern Asia region [94].