PNPLA3 and liver disorder: De Vincentis et al. examined the UKB cohort (n = 266,687) and showed that the HFC-PRS (including PNPLA3, TM6SF2, MBOAT7, and GCKR) was highly related to the risk of severe liver disease in the overall population (age–sex-adjusted HR (aHR) for a 1 SD increase: 1.25; 95% CI, 1.16–1.35; p = 8.9 × 10−9) [96].