The PRS (high-risk variants in PNPLA3-MBOAT7-TM6SF2-GCKR) exhibited by cirrhosis patients in the highest tertile corresponded to a 2-fold higher risk of HCC (HR = 2.05; 95% CI, 1.22–3.44) (Table 3). This evidence concerns the gene PNPLA3 and Cirrhosis.