MACC1 and lung adenocarcinoma: In lung adenocarcinoma, hnRNPH1 interacts with the MACC1 protein (via its GYR domain binding to the MACC1 SH3 domain) to prevent the skipping of exon 11 in the IRAK1 gene’s pre-mRNA, thereby promoting the production of the oncogenic IRAK1-L isoform, driving tumorigenesis [44].