COL4A1 and colorectal carcinoma: Beyond ion channel alterations, our study revealed significant dysregulation of key fibrous ECM components in CRC, with notable overexpression of collagen genes (COL5A2, COL1A1, COL4A1, COL6A3, and COL15A1) and laminin subunits (LAMA5 and LAMC1) [47].