ESR1 and neoplasm: Another work confirming lack of correlation between NUDT1 expression in breast cancer with the tumor grade or metastatic potential comes from Wani et al. This study shows significantly increased levels of mRNANUDT1 in tumor tissues, with non-detectable levels in normal ductal cells and expression of NUDT1 in 30–80% of cancer cells, but this upregulation was not directly linked to the expression of Cyclin D1, D3, estrogen receptor, p53, ki67 or HER2 [38].