CD163 and acquired polycythemia vera: Van Egeran et al. [43] demonstrated the pathogenic proinflammatory, profibrotic phenotype in the bone marrow monocyte, which are mostly of the intermediate phenotype, while Fan et al. [44] found significant transcriptional differences of monocytes/macrophages in the bone marrow of PV patients when compared to healthy control bone marrow with an increase in CD14+CD16+ and CD163+ cells.