Upon challenge with various anticancer drugs, increased Cer glycosylation and cellular GSLs can up-regulate the expression of particular genes, including multidrug resistance 1 (MDR1, also known as ABCB1), fibroblast growth factor 2 (FGF2), and even p53 mutants, protecting cancer cells against chemotherapy [8,9,10]. Here, ABCB1 is linked to cancer.