Indeed, key intermediate metabolites involved in AGE formation, such as MGO and GO, tend to increase in fasting glucose disorders and type 2 diabetes associated with abnormalities in AMPK-based metabolic systems in the liver and are implicated as causes of chronic oxidative damage related to lipid peroxidation and ferroptosis pathways [60]. The gene discussed is PRKAA1; the disease is type 2 diabetes mellitus.