Likewise, Acanthoside K3, a triterpenoid glycoside, has demonstrated a wide range of bioactivities, including suppression of tAGE–RAGE signaling, inhibition of NLRP3-mediated pyroptosis in ulcerative colitis, anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages, and neuroprotective effects in scopolamine-induced amnesia models via activation of the TrkB–CREB–BDNF pathway [84,85,86]. Here, CREB1 is linked to ulcerative colitis.