Figure 1 depicts the COO classification determined by the GEP and genetic classification of DLBCL samples into groups EZB, MCD, BN2, and N1 based on alterations in EZH2, BCL2, MYD88, CD79B, BCL6, NOTCH2, and NOTCH1. The gene discussed is NOTCH1; the disease is diffuse large B-cell lymphoma.