ALOX5 and cancer: Summarizing the results of molecular docking, we could speculate that SDA exerts its antitumor effects as follows: (1) reducing pro-inflammatory eicosanoids (by inhibiting COX-2 and ALOX5); (2) activating PPAR-γ, leading to metabolic stress and cell cycle arrest/interruption; (3) altering the properties of cancer cell membranes (disruption of lipid rafts); and (4) inducing apoptosis (by BAX, Bcl-2 and caspases).