Also, in a male murine model of AAA induced by topical CaCl2 application and Ang II-infusion, AAA formation, aortic inflammation, macrophages infiltration, and IL-6 expression were exacerbated in castrated mice and flutamide-implanted intact mice and prevented in T-treated mice, suggesting that selective AR modulators might be useful in aortic pathologies [457]. The gene discussed is IL6; the disease is triple-A syndrome.