Also, of the nine biomarkers were found to be positively associated with early menopause, five with an increased risk of future heart failure (adrenomedullin, adipsin, β2M, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and C-reactive protein (CRP)), and four with major CVD (adipsin, β2M, NT-proBNP, and CRP), suggesting that distinct biological pathways may make women with early menopause more susceptible to CVD [68]. The gene discussed is NPPB; the disease is heart failure.