A study by Luzi et al. [15] hypothesized the existence of an autoregulatory mechanism involving miR-24-3p, MEN1 mRNA, and menin, which appears to mimic the second Knudson’s hit in tissues in which MEN1 LOH has not yet occurred, thereby triggering the onset of parathyroid hyperplasia/adenoma, in an epigenetic and still reversible manner, before the irreversible genetic MEN1 LOH occurs. The gene discussed is MEN1; the disease is parathyroid hyperplasia.