NEFL and spinocerebellar ataxia 7: We observed a significant increase in both plasma (median of 21.6 pg/mL) and CSF (median of 2615 pg/mL) NfL levels in patients with SCA7 compared to the controls (median plasma: 8.2 pg/mL; median CSF: 414.6 pg/mL; Figure 1C and Table 1).