Trends of higher plasma and CSF GFAP levels were observed in symptomatic SCA7 patients compared to the healthy controls (Figure 1A), where the median plasma and CSF GFAP concentrations were 82.7 and 9318 pg/mL, respectively, in SCA7 compared to 48 and 8906 pg/mL in the plasma and CSF of controls (Table 1). Here, GFAP is linked to spinocerebellar ataxia 7.