The inflammatory responses against sepsis were less severe in cGAS−/− compared to WT mice, as indicated by reduced (i) liver dysfunction, using serum aspartate transaminase (AST) and alanine transaminase (ALT) levels, (ii) total white blood cells (WBC) and lymphocyte counts, and (iii) cytokine levels (TNF-α, IL-6, and IL-10). This evidence concerns the gene TNF and Sepsis.