Although there might be potential off-target effects from other immune cell populations in cGAS−/− mice different from the more myeloid cell-specific knockout model (e.g., LysM-Cre-driven cGAS deletion), macrophages are important immune cells responsible for sepsis [46], and studies in cGAS−/− mice (an easier gene-manipulated model) can be used as proof-of-concept studies. Here, CGAS is linked to Sepsis.