HRK and melanoma: Clustering analysis was performed on the DEGs, with results shown in Figure 6B. Treatment with rFIP-gle2 enhanced the expression of genes that inhibit cell proliferation and promote apoptosis in melanoma cells, such as Bcl2l11, Bcl2l13, Bok, Bmf, Hrk, Naif1, Fas, Casp 8, Casp 9, Casp 3, Casp 6, and Fasn.