FGF21 and type 2 diabetes mellitus: While short-term elevations in FGF21 are typically adaptive, persistently elevated levels of FGF21 have been associated with states of metabolic dysfunction such as type 2 diabetes (T2D) and possibly also be associated with metabolic-dysfunction-associated steatotic liver disease/metabolic-dysfunction-associated steatohepatitis (MASLD/MASH) [2,9,10,11,12].