Other covariates, including age, sex, C-reactive protein, essential hypertension, angina pectoris, chronic ischemic heart disease, heart failure, atherosclerosis, type 2 diabetes mellitus, and obesity, showed no statistically significant association with the hazard of NAFLD incidence (all p > 0.05). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.