C3 and complement 3 glomerulopathy: C3 glomerulopathy (C3G) accounts for the majority of complement-mediated MPGN [2], and it is considered a rare disorder caused by genetic or acquired dysregulation in one or more of the multiple components of the alternative complement pathway (AP), histopathologically marked by the accumulation of the C3 complement factor in kidney tissue in the near absence of immunoglobulin deposits and with classic clinical features of glomerulonephritis [3].