BCL2 and gastric cancer: For instance, Yu et al. found that Se-β-lactoglobulin had a significant cytotoxic effect on human gastric cancer MGC-803 cells by inducing caspase-dependent cell apoptosis, increasing the levels of intracellular ROS and Bax, and down-regulating the expression of Bcl-2, triggering the mitochondrial apoptosis pathway mediated by Bax and Bcl-2 [36].