IDUA and Scheie syndrome: Mucopolysaccharidosis type I (MPS I) is an autosomal-recessive disease that presents with chronic, progressive, multisystem, lysosomal storage caused by deficiency or lack of activity of the α-L-iduronidase (IDUA) enzyme [81,82,83,84], and resveratrol was shown to upregulate IDUA activity [85], providing a potential treatment option for MPSI.