Simultaneously, genes associated with maintaining cell population balance, such as SPNS2 (PAI 6: Vertebrata) [54,55] and STAT5B (PAI 6: Vertebrata) [56,57], as well as xenobiotic response genes like CYP3A4 (PAI 7: Euteleostomi) [58,59] and GLYAT (PAI 9: Eutheria) [60,61,62] and UGT1 family glucuronosyltransferases (PAI 7: Euteleostomi) [63,64] show down-regulation in the intermediate tumor stages. The gene discussed is SPNS2; the disease is neoplasm.