Both viruses can suppress type I IFN signaling to implement the immune evasion strategy, facilitating the establishment of virus infection status: HSV-ICP34.5 blocks STAT1/STAT2 activation and dephosphorylates eIF2α to resist the PKR pathway and HSV-ICP0, ICP27, and UL41 suppress IFN-β expression by interfering with IRF3/7 [68]. The gene discussed is IRF3; the disease is viral infectious disease.