Gene expression analysis of intra-lesional microvessels from patients with MS showed an increased expression of inflammatory factors including MMP (matrix metalloproteinase)2, MMP14, ADAM17 (disintegrin and metalloproteinase domain-containing protein 17), VEGF-A, and VEGFR1 (vascular endothelial growth factor receptor 1) [61], suggesting that inflammation could trigger cerebral hypoperfusion and hypoxia [62,63,64]. This evidence concerns the gene FLT1 and myeloid sarcoma.