DCT and melanoma: Peinado et al. in their paper, isolated circulating exosomes from the plasma of human patients affected by melanoma at different stages, identifying the presence of very late antigen 4 (VLA4), heat-shock protein 70 (HSP70; an HSP90 isoform), MET oncoprotein, and tyrosinase-related protein 2 (TYRP2), defining their composition [29].