HIF1A and lactic acidosis: Hypoxia, a chemoresistance factor, involves mechanisms such as HIF-1α [41], microRNA suppression [25], MDR-1 overexpression [42,43,44,45,46], lactic acidosis [47,48], NF-κB overexpression [49], changes in mitochondrial dynamics [50,51], and dysregulated glycolysis [52].