In high-risk cases of PDR, neovascularization may be present on greater than one third of the area of the optic disk, with hemorrhages obscuring greater than the area of one optic disk [23].All in all, VEGF plays a significant role in proliferative diabetic retinopathy, as well as several other microvascular conditions of the retina, as it increases vascular permeability, creates fragile blood vessels, enhances inflammation, and alters blood flow, all leading to the progression of this disease and eventual permanent impairment of a person’s vision [26]. Here, VEGFA is linked to proliferative diabetic retinopathy.