LAMP2 and Danon disease: In Danon disease, which is caused by a deficiency of lysosome-associated membrane protein 2 (LAMP2), Kwong-Man Ng et al. demonstrated that iPSC-CMs deficient in LAMP2 recapitulate key pathological features, including lysosomal storage defects and cardiomyocyte hypertrophy, consistent with the clinical cardiac phenotype [110].