So, we performed the multiple linear regression analysis for EDSS, MSSS and gARMSS in male PMS patients with model that includes: disease duration, age at MS onset, DYSF-ZNF638 locus rs10191329 C/A according to A allele dominant model and presence of HLA-DRB1*15:01 rs3135388 risk A allele (Table 4). The gene discussed is ZNF638; the disease is premenstrual tension.