In this study, we investigated gene variants proposed to be regulatory for CDKN1A, EGLN2 and MAP1B, the top three DEGs derived from our previous research of 138 ferroptosis-related genes between RRMS and SPMS, and which have been found to be associated with MS severity in recent GWASs [2,6]. This evidence concerns the gene EGLN2 and myeloid sarcoma.